Endocrine Abstracts

Background: Intracranial Germ Cell Tumors (GCTs) are thought to originate from error of primordial germ cells migration during embryonic development, manifesting during first and second decade of life and accounts for 3-5% of all intracranial tumors.Methods: We report a case of a 22-year-old patient who presented with progressive visual loss with polyuria and polydipsia, harboring an intracranial germ cell tumor.Case presentation: ...

Objectives: to evaluate the clinical and biochemical effects of (SGLT2) inhibitors as a fourth oral anti-diabetic drug in patients with type 2 diabetes mellitus (T2DM).Patients (Materials) and Methods: In a tertiary hospital in Karachi, Pakistan, a retrospective assessment of patient medical records was conducted from January 1, 2017 to December 31, 2020.A total of 100 patients (mean age [Standard Deviation]: 53.8 [9.63] years) with poorly controlled T2D...

Introduction: Hypothyroidism is a common endocrine disorder worldwide. Its treatment is with oral thyroxine, but when this route cannot be utilised then intravenous thyroxine is an alternate but not available in some countries so rectal thyroxine administration can be used but clinical experience is lacking.Case report: This is a case of a 55-years-old Pakistani male known case of hypothyroidism since July 2007 and was maintaining normal TSH and FT4...

Introduction: A thyroid ultrasound scan is recommended in the assessment of any suspected thyroid nodule. The ultrasound characteristics of nodules have been shown to be useful in assessing their malignant potential. The aim of this study is to determine diagnostic validity of thyroid ultrasound in differentiating benign and malignant thyroid nodule.Material and Methods: It was cross-sectional study, conducted at XXXX Hospital from August 2011 to July 20...

BackgroundPituitary gonadotroph adenomas are common but very rarely do they secrete biologically active luteinizing hormone (LH) and follicle-stimulating hormone (FSH). There have been case studies reporting high sex hormones (testosterone/estrogen) in the presence of high or normal LH and FSH.Case presentationHere we report two cases who presented with visual disturbance and headache at a tertiary care hospi...

Background: Idiopathic Hypogonadotropic Hypogonadism (IHH) is a condition caused by deficiency or insensitivity to gonadotropin-releasing hormone where the pathology behind the mechanism is unknown and no secondary causes of hypogonadotropic hypogonadism are present. The condition not only effect sexual characteristic but can affect the physical and psychosocial development of a patient therefore making its prompt diagnoses and treatment necessary. The purpose of this study wa...

Background: Primary adrenal insufficiency (PAI) is most commonly congenital in children. PAI is genetically heterogeneous with some gene defects causing syndromic disease. A third of patients have no genetic diagnosis rendering their prognosis uncertain. We investigated families with a novel combination of PAI and steroid resistant nephrotic syndrome.Objective and hypotheses: To discover the genetic defect underlying this syndrome....

Background: Primary adrenal insufficiency (PAI) is most commonly congenital in children. PAI is genetically heterogeneous with some gene defects causing syndromic disease. A third of patients have no genetic diagnosis meaning their prognosis is uncertain. We recently investigated families with a novel combination of PAI and steroid resistant nephrotic syndrome.Objective and hypotheses: To discover the genetic defect underlying this syndrome.<p class=...